姓名：李兰
职 称：副教授
学院系所：生命科学学院
学科领域：发育生物学
联系电话：0532-88030246
电子邮件：lilan9600@126.com
通讯地址：山东省青岛市城阳区长城路700号
青岛农业大学生命科学学院/生物楼C410
1、个人简介：
李兰，博士，副教授，硕士生导师。主要从事动物生殖毒理学的研究工作，主持国家自然科学基金、863项目子课题等4项，在《Toxicology and Applied Pharmacology》、《Theriogenology》、《Histochemistry and Cell Biology》、《Reproduction Fertility and Development》等国际刊物上发表SCI收录的研究论文50余篇，是《Journal of Proteomics》、《Reproductive Biology & Endocrinology》等10余种国际刊物的特邀审稿人。
2、工作经历：
2018-至今，青岛农业大学生命科学学院，副教授
2017-2017，青岛农业大学动物科技学院，高级实验师
2012-2016，青岛农业大学动物科技学院，实验师
2007-2011，青岛农业大学动物科技学院，助理实验师
2000-2005，军事医学科学院生物工程研究所，实验员
3、学习经历：
2012-2016，西北农林科技大学动物科技学院，博士
2005-2007，青岛农业大学动物科技学院，硕士
1996-2000，西北农林科技大学动物科技学院，学士
4、教学工作：
为本科生教授《动物生理学》、《动物生理学实验》、《动物繁殖学》、《动物繁殖学实验》等课程。
5、研究方向：
饲料霉菌毒素危害动物卵泡发育的机制及挽救技术
6、科研项目：
国家自然科学基金面上项目：赤霉烯酮暴露妊娠母猪影响胎儿卵母细胞发生的分子机制
国家自然科学基金青年基金：胰岛素通过Akt信号通路调节卵泡形成与发育激活的分子机制
国家863计划项目子课题：家畜卵泡诱导发育技术研究与应用
横向课题：环境类雌激素危害生殖健康的发生机制及挽救技术研究
7、近5年发表的论文（10篇）：
Rui-Qian Zhang, Xiao-Feng Sun, Rui-Ying Wu, Shun-Feng Cheng, Guo-Liang Zhang, Qiu-Yue Zhai, Xue-Lian Liu, Yong Zhao, Wei Shen, Lan Li *. Zearalenone exposure elevated the expression of tumorigenesis genes in mouse ovarian granulosa cells. Toxicology and Applied Pharmacology, 2018, 356: 191-203.
Xue-Lian Liu, Rui-Ying Wu, Xiao-Feng Sun, Shun-Feng Cheng, Rui-Qian Zhang, Tian-Yu Zhang, Xi-Feng Zhang, Yong Zhao, Wei Shen, Lan Li*. Mycotoxin zearalenone exposure impairs genomic stability of swine follicular granulosa cells in vitro. International Journal of Biological Sciences, 2018 Feb 12; 14(3): 294-305.
Guo-Liang Zhang, Jun-Lin Song, Yi Zhou, Rui-Qian Zhang, Shun-Feng Cheng, Xiao-Feng Sun, Guo-Qing Qin , Wei Shen, Lan Li *. Differentiation of sow and mouse ovarian granulosa cells exposed to zearalenone in vitro using RNA-seq gene expression. Toxicology and Applied Pharmacology, 2018, July 1, 350: 78-90
Kehan Liu (#), Xiaofeng Sun (#), Yanzhong Feng, Shunfeng Cheng, Bo Li, Yapeng Li, Wei Shen, Lan Li (*). The impact of zearalenone exposure on the meiotic progression and primordial follicle assembly during early oogenesis. Toxicology and Applied Pharmacology, 2017 Aug 15; 329: 9-17.
Guoliang Zhang, Xiaofeng Sun, Yanzhong Feng, Bo Li, Yapeng Li, Fan Yang, Martin C Nyachoti, Wei Shen, Shiduo Sun(*), Lan Li(*). Zearalenone exposure impairs ovarian primordial follicle formation via down-regulation of Lhx8 expression in vitro. Toxicology and Applied Pharmacology, 2017 Feb 15; 317: 33-40.
Pengfei Zhang, Yong Zhao, Shuai Yu, Jing Liu, Yanan Hao, Hongfu Zhang, Wei Ge, Lingjiang Min, Wei Shen, Qunjie Li, Xin Kou, Huanfa Ma, Lan Li (*). Proteome analysis of egg yolk after exposure to zinc oxide nanoparticles. Theriogenology, 2017 Jun, 95: 154-162.
Weidong Zhang#, Yong Zhao#, Hongfu Zhang, Shukui Wang, Zhihui Hao, Jingcai Liu, Yuqing Yuan, Pengfei Zhang, Wei Shen, Lan Li (*). Alteration of gene expression by zinc oxide nanoparticles or zinc sulfate in vivo, and comparison with in vitro data-a harmonious case. Theriogenology, 2016 Aug; 86(3): 850-861.
Lan Li, Jingcai Liu, Fangnong Lai, Huanqi Liu, Xifeng Zhang, Paul W. Dyce, Wei Shen, Hong Chen (*), Di (2-ethylhexyl) phthalate exposure impairs growth of antral follicle in mice. PLoS One, 2016 Feb 4, 11(2): e0148350
Lan Li, Jingcai Liu, Yong Zhao, Fangnong Lai, Fan Yang, Wei Ge, Chengli Dou, Wei Shen, Xifeng Zhang (*), Hong Chen (*)，Impact of diethylhexyl phthalate on gene expression and development of mammary glands of pregnant mouse. Histochemistry Cell Biology, 2015 Oct, 144(4): 389-402
Xunsi Qin (#), Mingjun Cao (#), Fangnong Lai, Fan Yang, Wei Ge, Xifeng Zhang, Shunfeng Cheng, Xiaofeng Sun, Guoqing Qin, Wei Shen, Lan Li (*), Oxidative stress induced by zearalenone in porcine granulosa cells and its rescue by curcumin in vitro. PLoS One, 2015 Jun 1, 10(6): e0127551
