肖志壮，博士，青岛农业大学生命科学学院客座教授，山东省泰山学者海外特聘专家，青岛首批英才计划入选者，蔚蓝生物集团研发中心副总经理。于2001年获山东大学微生物学博士学位后，到加拿大不列颠哥伦比亚大学作博士后。后来进入加拿大国立研究委员会生物技术研究所先后担任客座研究员、研究员。在开发多种新型酶制剂方面包括纤维素酶、半纤维素酶、淀粉酶、果胶酶等具有丰富的经验。开发出应用于饲料、食品、纺织和造纸工业的多种新型酶制剂，获美国专利1项。肖志壮博士在国外SCI刊物上发表了12篇论文，影响因子总数30以上，共被引用200多次。回国后，带领团队开发出多种国际先进的酶制剂产品，并主持参与两项科技部863项目的课题。

 

 

  

微生物学博士                                     山东大学          1998-2001年

生物化学硕士                                     北京大学          1989-1992年

微生物学学士                                     山东大学          1985-1989年

 

资深科学家、技术中心副主任       青岛蔚蓝生物技术中心                2011年至今

研究官员 （科学家）          加拿大国立研究委员会生物技术研究所   2009年-2010年

科学家                       杰能科中国研究中心                    2008年

研究官员 （科学家）          加拿大国立研究委员会生物技术研究所   2007-2008年

客座研究员                   加拿大国立研究委员会生物技术研究所   2005-2007年

博士后研究员                 加拿大Concordia University           2003-2005年

博士后                       加拿大University of British Columbia 2001-2003年

讲师                                               烟台大学                             1992-1998 年

 

 

山东省泰山学者海外特聘专家

青岛农业大学客座教授

 

 

 

 

1.    Xiao Z, Wang S, Bergeron H, Zhang J, Lau P. (2008) A flax-retting endo-polygalacturonase-encoding gene from Rhizopus oryzae. Antonie Van Leeuwenhoek  94：563-571.

2.    Xiao Z, Boyd J, Grosse S, Beauchemin M, Coupe E, Lau P. (2008) Mining Xanthomonas and Streptomyces genomes for new pectinase-encoding sequences and their heterologous expression in Escherichia coli. Applied Microbiology and Biotechnology 78: 973-981.

3.    Xiao Z, Bergeron H, Grosse S, Beauchemin M, Garron M, Shaya D, Sulea T, Cygler M, Lau P. (2008) Improving the thermostability and activity of a pectate lyase by single amino acid substitutions using a strategy based on T_M – guided sequence alignment. Applied and Environmental Microbiology 74: 1183-1189.

4.    Xiao Z, Bergeron H, Grosse S, Lau P. (2008) Pectate lyases with improved thermostability and/or enzymatic activity.  US Patent pending.

5.    Lahjouji K, Storms R, Xiao Z, Joung K, Zheng Y, Powlowski J, Tsang A, Varin L. (2007). Biochemical and molecular characterization of a cellobiohydrolase from Trametes versicolor. Applied Microbiology and Biotechnology 75: 337-346.

6.    Xiao Z, Storms R, Tsang A.  (2006). A quantitative starch-iodine method for measuring alpha-amylase and glucoamylase activities.  Analytical Biochemistry 351: 146-148.

7.    Xiao Z, Storms R, Tsang A.  (2005). Microplate-based carboxymethylcellulose assay for endoglucanase activity. Analytical Biochemistry 342: 176-178.

8.    Pan X, Arato C, Gilkes N, Gregg DJ, Mabee WE, Pye K, Xiao Z, Zhang X, Saddler JN. (2005) Biorefining of softwoods using ethanol organosolv pulping - preliminary evaluation of process streams for manufacture of fuel grade ethanol and co-products. Biotechnology and Bioengineering 90: 473-481.

9.    Xiao Z, Storms R, Tsang A.  (2004). Microplate-based filter paper assay to measure total cellulase activity. Biotechnology and Bioengineering. 88 (7): 832-837.

10.  Xiao Z, Zhang X, Gregg D and Saddler JN. (2004) Effects of sugar inhibition on cellulases and beta-glucosidase during enzymatic hydrolysis of softwood substrates. Applied Biochemistry and Biotechnology. 115(1-3):1115-26

11.  Xiao Z, Wang P, Qu Y, Gao P, Wang T.  (2002) Cold adaptation of a mesophilic cellulase, EG III from Trichoderma reesei, by directed evolution.    Science in China, Series C: Life Sciences 45 (4): 337-343.

12.  Xiao Z, Gao P, Qu Y, Wang T.  (2001) Cellulose-binding domain of endoglucanase III from Trichoderma reesei disrupting the structure of cellulose.    Biotechnology Letters 23 (9): 711-715.

13.  Xiao Z, Wang T, Wang T, Qu Y, Gao P.  (2001) Cloning and expression of Trichoderma reesei endoglucanase III gene in Saccharomyces cerevisiae.  Acta Microbiologica Sinica   41 (4): 391-396.

14.  Xiao Z, Wu Z, Wang T, Qu Y, Gao P, Wang T. (2001) Effect of 3'-UTR of cellobiohydrolase I from Trichoderma reesei on its gene expression in Saccharomyces cerevisiae.    Acta Microbiologica Sinica 41 (5): 587-591.

15.  Xiao Z, Qu Y, Wang T, Gao P, Liu M.  (2001) Excessive DMSO dramatically reducing specificity of PCR amplification at low concentration of template.    Heredity (Beijing) 23 (4): 341-343.

16.  Xiao Z, Wang T, Wang P, Qu Y, Gao P. (2001) Novel strategy for screening mutant enzyme under non-growth condition.    Microbiology (Beijing) 28 (5): 74-77.

17.  Xiao Z, Liu M, Wang T, Qu Y.  (2001) Advances in study on directed evolution of proteins.    Advances in Biotechnology (Beijing) 21 (6): 31-33, 56.