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Caroline Stone Harwood

2018-03-12 20:07:21 来源：生命科学学院浏览数：0

Caroline S. Harwood，女，博士，美国科学院院士，美国华盛顿大学教授，博士生导师，青岛农业大学“特聘教授”，“山东省高端外国专家”。
Caroline S. Harwood博士于2000年当选为美国微生物学会资深会员，2008年当选为美国科学促进会(AAAS)资深会员，2009年被评为美国科学院院士（Elected Member, National Academy of Sciences），2010年获宝洁公司应用环境微生物学奖。Harwood院士在微生物生理学及生物能源领域享有国际声誉。其研究工作已在国际著名期刊（如Science, Nature, Nature Biotechnology, PNAS, mBio, Nucleic Acids Research, Curr.Opinion in Microbiol., Appl. Environ. Microbiol. J. Bacteriol.等）发表SCI论文100多篇，其中单篇文章最高他引次数达500多次。目前正在主持来自美国能源部（DOE）、国家卫生研究所、陆军研究局、美国国家科学基金等多项课题，总经费达450多万美元。

一、学习经历：

1978/06-1982/06, 麻省大学( University of Massachusetts )，微生物学(Microbiology)，博士。

1973/06-1976/06, 波士顿大学( Boston University)，生物学(Biology)，硕士。

1970/09-1973/06, 科尔比学院( Colby College, Waterville )，生物学(Biology)，学士。

二、工作经历

2017/02-至今，青岛农业大学(Qingdao Agricultural University)，生命科学学院，特聘教授

2005/01-至今，华盛顿大学(University of Washington)，微生物学系，教授

1996/06-2004/12，爱荷华大学( University of Iowa )，微生物学系，教授

1993/07-1996/05，爱荷华大学( University of Iowa )，微生物学系，副教授

1988/08-1993/06，爱荷华大学( University of Iowa )，微生物学系，助理教授

1984/08-1988/07，康奈尔大学(Cornell University)，微生物学系，高级研究助理

1982/06-1984/09，耶鲁大学(Yale University)，微生物学系，博士后

三、国际专业组织：

2011-2015 美国微生物学会执行主席

2010-2015 美国微生物学会执行委员

2009- 在ASM出版社（美国微生物学会出版社）委员会担任主席

2004-2009 在AMS出版社担任主席

2001-2003 当选美国微生物学会第四分组代表 (分子生物学, 生理学 & 病毒学),

1996-1998 当选美国微生物学会的 K分会主席(微生物生理学)

四、国际期刊任职:

2017- 美国科学院院报（PNAS）编委

2013- mBIO编辑

2011-2012 《细菌学期刊》编辑

2008-2011 《分子微生物学》编辑顾问委员会成员

2005- 《微生物年刊》的副主编

1996-2006 《应用与环境微生物学》编委

1993-1996 《细菌学期刊》编辑

1991-1996 《应用与环境微生物学》编辑

五、科研工作简介
（1）光合细菌生产生物能源

（2）微生物生理学（生物电子转移和催化作用）

（3）群体感应系统研究

近年主持科研项目

（1）植物微生物界面: 橡树岭国家实验室项目的子课题美国能源部（DOE）执行时间: 5/1/15-4/30/16 $693,510

（2）不动杆菌属未定性基因的功能国家卫生研究所 (NIAID U19) 执行时间:7/1/13-6/30/18 $1,315,090

（3）光合细菌生产生物能源. 支持来源: DOE/BES D 8/01/13-9/31/16 $510,000

（4）能源前沿研究中心的生物电子转移和催化作用美国能源部（DOE）/基础能源科学: DE-SC0012518 执行时间: 8/01/14-9/31/18 $772,000

（5）非生长状态细菌的蛋白修复: 生物能源生产过程中的应用. 陆军研究局（DOD/Amy Research Office）: W911NF-15-1-0150 执行时间: 6/01/15-5/30/18 $520,000

主要学术论文（“*”代表通讯作者）

Zaira Martín-Moldes, Blas Blázquez, Claudine Baraquet, Caroline S. Harwood, María T. Zamarro, and Eduardo Díaz. 2016, Degradation of cyclic diguanosine monophosphate by a hybrid two-component protein protects Azoarcus sp. strain CIB from toluene toxicity. Proc. Natl. Acad. Sci. USA. 113(46): 13174- 13179.

Kathryn R. Fixen, Yanning Zheng, Derek F. Harris, Sudipta Shaw, Zhi-Yong Yang, Dennis R. Dean, Lance C. Seefeldt, and Caroline S. Harwood，2016， Light-driven carbon dioxide reduction to methane by nitrogenase in a photosynthetic bacterium，Proc. Natl. Acad. Sci. USA. 113(36):10163-10167.

Amy L. Schaefer, Yasuhiro Oda, Bruna Goncalves Coutinho, Dale A. Pelletier, Justin Weiburg, Vittorio Venturi, E. Peter Greenberg, Caroline S. Harwood. 2016. A LuxR Homolog in a Cottonwood Tree Endophyte That Activates Gene Expression in Response to a Plant Signal or Specific Peptides. mBio,7(4): e01101-16.

Bruno Y. Matsuyamaa,, Petya V. Krasteva, Claudine Baraquet, Caroline S. Harwood, Holger Sondermann, and Marcos V. A. S. Navarro. 2015. Mechanistic insights into c-di-GMP–dependent control of the biofilm regulator FleQ from Pseudomonas aeruginosa. Proc. Natl. Acad. Sci. USA.: E209–E218.

Kieran B. Pechter, Larry Gallagher,Harley Pyles, Colin S. Manoil, Caroline S. Harwood. 2016. Essential Genome of the Metabolically Versatile Alphaproteobacterium Rhodopseudomonas palustris. Journal of Bacteriology,198(5):867-876.

Claudine Baraquet, Caroline S. Harwood. 2016. FleQ DNA Binding Consensus Sequence Revealed by Studies of FleQDependent Regulation of Biofilm Gene Expression in Pseudomonas aeruginosa. Journal of Bacteriology,198(1):178-186.

Heiniger, E. K., and C. S. Harwood. 2015. Posttranslational modification of a vanadium nitrogenase. MicrobiologyOpen. In press.

Hirakawa H, Hirakawa Y, Greenberg EP, Harwood CS. 2015. BadR and BadM proteins transcriptionally regulate two operons needed for anaerobic benzoate degradation by Rhodopseudomonas palustris. Appl Environ Microbiol. Apr 17. pii: AEM.00377-15. [Epub ahead of print]

Chen, A.I., E. F Dolben, C. Okegbe, C. E. Harty, Y. Golub, S. Thao , D. G. Ha, S. D. Willger, G.

1. 1. O’Toole, C. S. Harwood, L. E. P. Dietrich and D. A. Hogan. 2014. Candida albicans ethanol stimulates Pseudomonas aeruginosa WspR-controlled biofilm formation as part of a cyclic relationship involving phenazines. Plos Pathogens 10(10): e1004480. doi:10.1371/journal.ppat.1004480

Fixen KR, A. W. Baker, E. A. Stojković, J. T Beatty, and C.S. Harwood. 2014. Apo- bacteriophytochromes modulate bacterial photosynthesis in response to low light. Proc. Natl. Acad. Sci. USA. 111: E237-44.

McKinlay JB, Y. Oda, M. Ruhl, AL Posto, U. Sauer and CS Harwood. 2014.Non-growing Rhodopseudomonas palustris increases the hydrogen gas yield from acetate by shifting from the glyoxylate shunt to the tricarboxylic acid cycle. J Biol Chem. 289:1960-70.

Baraquet, C. and C. S. Harwood. 2013. C-di-GMP represses bacterial flagella synthesis by interacting with the Walker A motif of the enhancer binding protein FleQ. Proc. Natl. Acad. Sci. USA. 110:18478-18483. PMID: 24167275

Schaefer, A, L., C.R. Lappala, R.P. Morlen, D.A. Pelletier, T.Y. Lu, P.K. Lankford, C.S. Harwood and E. P. Greenberg. 2013. LuxR- and LuxI-type quorum sensing circuits are prevalent in members of the Populus deltoides microbiome. Appl. Environ. Microbiol. 79:5745- 4752. PMID: 23851092

Huangyutitham, V., Z, T, Guvener, and C. S. Harwood. 2013. Subcellular clustering of the phosphorylated WspR response regulator protein stimulates its diguanylate cyclase activity. mBIO. May 7;4(3). doi:pii: e00242-13. 10.1128/mBio.00242-13.

Irie Y, B. R. Borlee, J. R. O'Connor JR, P. J. Hill, C S. Harwood, D. J. Wozniak and M. R. Parsek. 2012. Self-produced exopolysaccharide is a signal that stimulates biofilm formation in Pseudomonas aeruginosa. Proc. Natl. Acad. Sci. USA. 109:E2823-31. PMID: 23175784

Adessi, A., J. B. McKinlay, C. S. Harwood and R. DePhilippis. 2012. A Rhodopseudomonas palustris nifA* mutant produces H2 from NH4+-containing vegetable wastes. Int. J. Hydrogen Energy Res. 37: 15893-900.

Chugai S., B. S. Kim, S. Phattarasukol, M. J. Brittnacher, S, H. Choi, C. S. Harwood and E.P. Greenberg. 2012. Strain-dependent diversity in the Pseudomonas aeruginosa quorum- sensing regulon. Proc. Natl. Acad. Sci. USA. 109:E2823-31

O’Connor, J., N. Kuwada, V. Huangyutitham, P. Wiggins, and C. S. Harwood. 2012. Surface sensing and lateral subcellular localization of WspA, the receptor in a chemosensory-like system leading to c-di-GMP production. Mol. Microbiol. Sep 7. doi: 10.1111/mmi.12013.

Phattrasukol, S., M.C. Radey, C. R. Lappala, Y, Oda, H. Hirakawa, M. J. Brittnacher, and C. S. Harwood. 2012. Identification of a p-coumarate degradation regulon in

Rhodopseudomonas palustris using Xpression, an integrated tool for prokaryotic RNA- seq data processing. Appl. Environ. Microbiol. 78:6812-8

Hirakawa, H., C. S. Harwood, K. B. Pechter, A. L. Schaefer and E. P. Greenberg. 2012. An antisense RNA that affects Rhodopseudomonas palustris quorum-sensing signal receptor expression. Proc. Natl. Acad. Sci. USA. 109:12141-6.

Baraquet, C., K. Murikami, M. R. Parsekj and C. S. Harwood. 2012. The FleQ protein from Pseudomonas aeruginosa functions as both a repressor and an activator to control gene expression from the pel operon promoter in response to c-di-GMP. Nucleic Acids Research. 40:7207-18.

Hirakawa H., A. L. Schaefer, E. P. Greenberg and C. S. Harwood. 2012. Anaerobic p- coumarate degradation by Rhodopseudomonas palustris and identification of CouR, a MarR repressor protein that binds p-coumaroyl-CoA. J. Bacteriol. 194: 1960-1967.

Heiniger, E. K., Y. Oda, S. K. Samanta and C. S. Harwood. 2012. How post-translational modification of nitrogenase is circumvented in Rhodopseudomonas palustris strains that produce hydrogen gas constitutively. Applied and Environ. Microbiol. 78:1023-32.

Lindemann, A., G. Pessi, A. L. Schaefer, M. E. Mattmann, Q.H. Christensen, A. Kessler, H. Hennecke, H. E. Blackwell, E. P. Greenberg and C. S. Harwood. 2011. Quorum sensing in the soybean root-nodulating bacterium Bradyrhizobium japonicum: identification of isovaleryl-homoserine lactone, an unusual branched-chain signal. Proc. Natl. Acad.

Sci. USA. 108:16750-16770.

Ahlgren, N. S., C. S. Harwood, A. L. Schaefer, E. Griaud, and E. P. Greenberg. 2011. Aryl- homoserine lactone quorum sensing in stem-nodulating photosynthetic bradyrhizobia. Proc. Natl. Acad. Sci. USA 108:7183-7188.

McKinlay, J. B. and C. S. Harwood. 2011. Calvin cycle flux, pathway constraints and substrate oxidation state together determine the H2 biofuel yield in photoheterotrophic bacteria. mBIO. March 22:2.

Hirakawa H, Y. Oda, S. Phattarasukol, C. D. Armour, J. C. Castle, C.K. Raymond, C. R. Lappala, A. L. Schaefer, C. S. Harwood and E. P. Greenberg. 2011. Activity of the Rhodopseudomonas palustris p-coumaroyl-homoserine lactone responsive transcription factor RpaR. J. Bacteriol. 193: 2598-2607.

Huang J.J., E. K. Heiniger, J. B. McKinlay and C. S. Harwood. 2010. Production of hydrogen gas from light and the inorganic electron donor thiosulfate by Rhodopseudomonas palustris. Appl. Environ. Microbiol. 76: 7717-7712.

Gosse, J.L., B. J. Engel, J. C. Hui , C. S. Harwood, and M. C. Flickinger. 2010. Progress toward a biomimetic leaf: 4,000 h of hydrogen production by coating-stabilized nongrowing photosynthetic Rhodopseudomonas palustris. Biotechnol Prog. 26:907-918.

McKinlay, J. B. and C. S. Harwood. 2010. Carbon dioxide fixation as a central redox cofactor recycling mechanism in bacteria. Proc. Natl. Acad. Sci. USA 105:18543-18548.

Crosby, H. A., Heiniger, E. K., C. S. Harwood, and J. C. Escalante-Semerana. 2010 Reversible N-lysine acetylation regulates the activity of acyl-CoA synthetases involved in anaerobic benzoate catabolism in Rhodopseudomonas palustris. Mol. Microbiol. 75: 1007-1020.

McKinlay, J. B. and C. S. Harwood. 2010. Photobiological production of hydrogen gas as a biofuel. Curr. Opin. Biotechnol. 21:244-251.

Rey, F. and C. S. Harwood. 2010. FixK, a global regulator of microaerobic growth, controls photosynthesis in Rhodopseudomonas palustris. Mol. Microbiol. 75:1007-1020.

Starkey M, J. H. Hickman, L. Ma, N. Zhang, S. De Long, A. Hinz A, S. Palacios, C. Manoil, M. J. Kirisits, T. D. Starner, D.J. Wozniak, C. S. Harwood, M. R. Parsek. 2009. Pseudomonas aeruginosa rugose small colony variants have adaptations likely to promote persistence in the cystic fibrosis lung. J. Bacteriol. 191: 3492-3503.

Oda Y., F. W. Larimer, P. S. Chain, S. Malfatti, M. V. Shin, L. M., Vergez, L. Hauser, M. L. Land, S. Braatsch, J. T. Beatty, D. A. Pelletier, A. L. Schaefer and C. S. Harwood. 2008. Multiple genome sequences reveal adaptations of a phototrophic bacterium to sediment microenvironments. Proc. Natl. Acad. Sci. USA. 105:18543-18548. Epub 2008 Nov 1

Schaefer, A. L., E. P. Greenberg, C. M. Oliver, Y. Oda, J. J. Huang, G. Bittan-Banin, C. M. Peres, S. Schmidt, K. Juhaszova, J. R. Sufrin and C. S. Harwood. 2008. A new class of homoserine lactone quorum-sensing signals. Nature 454:595-599.

Hickman, J. W. and C. S. Harwood. 2008. Identification of FleQ from Pseudomonas aeruginosa

as a c-di-GMP-responsive transcription factor. Mol. Microbiol. 69:376-389.

Pan, C., Y. Oda, P. K. Lankford, B. Zhang, N. F. Samatova, D. A. Pelletier, C. S. Harwood, and R.L. Hettich. 2008. Characterization of anaerobic catabolism of p-coumarate in Rhodopseudomonas palustris by integrating transcriptomics and quantitative proteomics. Mol. Cell. Proteomics. 7:938-948.

Güvener, Z. T. and C. S. Harwood. 2007. Subcellular location characteristics of the Pseudomonas aeruginosa GGDEF protein, WspR, indicate that it produces cyclic-di- GMP in response to growth on surfaces. Mol. Microbiol. 66:1459-147.

Alvarez-Ortega, C. and C. S. Harwood. 2007. Identification of a malate chemoreceptor in Pseudomonas aeruginosa by screening for chemotaxis defects in an energy taxis- deficient mutant. Appl. Environ.Microbiol. 73:7793-7795.

Alvarez-Ortega, C. and C. S. Harwood. 2007. Responses of Pseudomonas aeruginosa to low oxygen indicate that growth in the cystic fibrosis lung is by aerobic respiration. Mol.

Microbiol.65:153-165.

Rey, F. E., E. K. Heiniger and C. S. Harwood. 2007. Redirection of metabolism for biological hydrogen production. Appl. Environ. Microbiol. 73:1665-1671.

Gosse, J. L., B. J. Engel, F. Rey, C. S. Harwood, L. E. Scriven and M. C. Flickinger, 2007 Hydrogen production by nano-porous laxtex coating of non-growing Rhodopseudomonas palustris CGA009. Biotechnology Prog. 23:124-130.

Braatsch, S., J. R. Bernstein, F. Lessner, J. Morgan, J. C. Liao, C. S. Harwood and J. T. Beatty.

2006. Rhodopseudomonas palustris CGA009 has two ppsR genes that each encode repressors of photosynthesis gene expression. Biochemistry 45: 14441-14451.

Peres. C. M. and C. S. Harwood. 2006. BadM is a transcriptional repressor and one of three regulators that controls benzoyl-CoA reductase gene expression in Rhodopseudomonas palustris. J. Bacteriol. 188:8662-8665.

Rey, F. E. , Y. Oda and C. S. Harwood. 2006. Regulation of uptake hydrogenase and effects of hydrogen utilization on gene expression in Rhodopseudomonas palustris. J. Bacteriol. 188: 6143-6152.

Güvener, Z.T., D. F. Tifrea and C. S. Harwood. 2006. Two different Pseudomonas aeruginosa chemosensory signal transduction complexes localize to cell poles and form and remold in stationary phase. Mol. Microbiol. 61:106-118.

VerBerkmoes, N. C., M. B. Shah, P. K. Lankford, D. A. Pelletier, M. B. Strader, D. L. Tabb, W.

H. McDonald, J. W. Barton, G. B. Hurst, L. Hauser, B. H. Davison, J. T.Beatty, C. S. Harwood, F. R. Tabita, R. L. Hettich, and F. W. Larimer. 2006 Determination and comparison of the baseline proteomes of the versatile microbe Rhodopseudomonas palustris under its major metabolic states. J. Proteome Research. 5:287-298.

Hickman J.W., D. F. Tifrea and C. S. Harwood. 2005. A chemosensory system that regulates biofilm formation through modulation of cyclic diguanylate levels. Proc. Natl. Acad. Sci. USA.102:14422-14427.

Oda, Y., S. K. Samanta, F. Rey, L. Wu, X.-D. Liu, T.-F. Yan, J. Zhou, and C. S. Harwood. 2005.

Functional genomic analysis of three nitrogenase isozymes in Rhodopseudomonas palustris. J. Bacteriol. 187:7784-7794.

Harrison, F.H. and C. S. Harwood. 2005. The pimFABCDE operon from Rhodopseudomonas palustris mediates dicarboxylic acid degradation and participates in anaerobic benzoate degradation. Microbiology 151:727-736.

Samanta, S. K. and C. S. Harwood. 2005. Use of the Rhodopseudomonas palustris genome to identify a single amino acid that contributes to the activity of a coenzyme A ligase with chlorinated substrates. Mol. Microbiol. 55:1151-1159.

Larimer, F. W., P. Chain, J. Lamerdin, S. Stilwagen Malfatti, L. Do, M. Land, L. Hauser, D. A. Pelletier, J. T. Beatty, A. S. Lang, F. R. Tabita, J. L. Gibson, T. E. Hanson, C. Bobst, J. Torres Y Torres, C. Peres, F. Harrison, J. Gibson and C. S. Harwood. 2004. The genome sequence of the metabolically versatile photosynthetic bacterium Rhodopseudomonas palustris. Nature Biotech. 22:55-61.

Schuster, M., A. C. Hawkins, C. S. Harwood and E. P. Greenberg. 2004. The Pseudomonas aeruginosa RpoS regulon and its relationship to quorum sensing. Mol. Microbiol.

51:973-985.

Ferrández,, A., A. C. Hawkins, D. T. Summerfield, and C. S. Harwood. 2002. Cluster II che genes from Pseudomonas aeruginosa are required for an optimal chemotactic response. J. Bacteriol. 184:4374-4383.

Ditty, J. L. and C. S. Harwood. 2002. Charged amino acids conserved in the aromatic acid/H+

symporter family of permeases are required for 4-hydroxybenzoate transport by PcaK from Pseudomonas putida. J. Bacteriol. 184:1444-1448

Hawkins, A.C. and C.S. Harwood. 2002. Chemotaxis of Ralstonia eutropha JMP134 (pJP4) to the herbicide 2,4-dichlorophenoxyacetate. Appl. Environ.Microbiol. 68: 968-972

Egland, P. G., J. Gibson and C. S. Harwood. 2001. A reductive, coenzyme A-mediated, pathway for 3-chlorobenzoate degradation in the phototrophic bacterium, Rhodopseudomonas palustris. Appl. Environ. Microbiol. 67: 1396-1399.

Parales, R. E., J. L. Ditty and C. S. Harwood. 2000. Toluene-degrading bacteria are chemotactic towards the environmental pollutants benzene, toluene, and trichloroethylene. Appl. Environ. Microbiol. 66:4098-104.

Cowles, C. E., N. N. Nichols and C. S. Harwood. 2000. BenR, a XylS homologue, regulates three different pathways of aromatic acid degradation in Pseudomonas putida. J. Bacteriol. 182:6339-6346.

Pelletier, D. A. and C. S. Harwood. 2000. 2-Hydroxycyclohexanecarboxyl coenzyme A dehydrogenase, an enzyme characteristic of the anaerobic benzoate degradation pathway used by Rhodopseudomonas palustris. J. Bacteriol. 182:2753-2760.

Nichols, N. N. and C. S. Harwood. 2000. An aerotaxis transducer gene from Pseudomonas putida. FEMS Microbiol. Letts. 182:177-183.

Egland, P. G. and C. S. Harwood. 2000. HbaR, a 4-hydroxybenzoate sensor and FNR-CRP superfamily member, regulates anaerobic 4-hydroxybenzoate degradation by Rhodopseudomonas palustris. J. Bacteriol. 182:100-106.

Ditty, J. L. and C. S. Harwood. 1999. Conserved cytoplasmic loops are important for both the transport and chemotaxis functions of PcaK, a protein from Pseudomonas putida with 12 membrane-spanning regions. J. Bacteriol. 181:5068-5074.

Grimm, A. C. and C. S. Harwood. 1999. NahY, a catabolic plasmid-encoded receptor required for chemotaxis of Pseudomonas putida to the aromatic hydrocarbon naphthalene. J. Bacteriol. 181:3310-3316.

Egland, P. G., and C. S. Harwood. 1999. BadR, a new MarR family member, regulates anaerobic benzoate degradation by Rhodopseudomonas palustris in concert with AadR, an Fnr family member. J. Bacteriol. 181:2102-2109.

Pelletier, D. A., and C. S. Harwood. 1998. 2-Ketocyclohexanecarboxyl-CoA hydrolase, the ring-cleavage enzyme required for anaerobic benzoate degradation by Rhodopseudomonas palustris. J. Bacteriol. 180:2330-2336.

Ditty, J. L., A. C. Grimm, and C. S. Harwood. 1998. Identification of a chemotaxis gene region from Pseudomonas putida. FEMS Microbiol. Letts. 159:267-273

Grimm, A. C., and C. S. Harwood. 1997. Chemotaxis of Pseudomonas spp. to the polyaromatic hydrocarbon naphthalene. Appl. and Environ. Microbiol. 63:4111-4115.

Nichols, N. N., and C. S. Harwood. 1997. PcaK, a high affinity permease for the aromatic compounds 4-hydroxybenzoate and protocatechuate from Pseudomonas putida. J. Bacteriol. 179:5056-5061.

Egland, P. G., D. A. Pelletier, M. Dispensa, J. Gibson, and C. S. Harwood. 1997. A cluster of bacterial genes for anaerobic benzene ring biodegradation. Proc. Natl. Acad. Sci.

USA 94:6484-6489.

Gibson, J., M. Dispensa, and C. S. Harwood. 1997. 4-Hydroxybenzoyl-CoA reductase (dehydroxylating) is required for anaerobic degradation of 4-hydroxybenzoate by Rhodopseudomonas palustris and shares features with molybdenum-containing hydroxylases. J. Bacteriol. 179:301-309.

Egland, P. G., J. Gibson, and C. S. Harwood. 1995. Benzoate-coenzyme A ligase, encoded by badA, is one of three ligases able to catalyze benzoyl-CoA formation during anaerobic growth of Rhodopseudomonas palustris on benzoate. J. Bacteriol. 177:6545-6551,

Nichols N. N., and C. S. Harwood. 1995. Repression of 4-hydroxybenzoate transport and degradation by benzoate: a new layer of regulatory control in the Pseudomonas putida

b-ketoadipate pathway. J. Bacteriol. 177:7033-7040.

Harwood, C. S., N. N. Nichols, M-K. Kim, J. L. Ditty, and R. E. Parales. 1994. Identification of the pcaRKF gene cluster from Pseudomonas putida, involvement in chemotaxis, biodegradation, and transport of 4-hydroxybenzoate. J. Bacteriol. 176:6479-6488.

Romero-Steiner, S., R. E. Parales, C. S. Harwood, and J. E. Houghton. 1994. Characterization of the pcaR regulatory gene from Pseudomonas putida, which is required for the complete degradation of p-hydroxybenzoate. J. Bacteriol. 176:5771-5779

Perrotta, J. A., and C. S. Harwood. 1994. Anaerobic metabolism of cyclohex-1-ene-1- carboxylate, a proposed intermediate of benzoate degradation by Rhodopseudomonas palustris. Appl. Environ. Microbiol. 60:1775-1782.

Gibson, J., M. Dispensa, G. C. Fogg, D. T. Evans, and C. S. Harwood. 1994. 4- Hydroxybenzoate-coenzyme A ligase from Rhodopseudomonas palustris: purification, gene sequence, and role in anaeroabic degradation. J. Bacteriol. 176:634-641.

Parales, R. E., and C. S. Harwood. 1993. Regulation of the pcalJ genes for aromatic acid degradation in Pseudomonas putida. J. Bacteriol. 175:5829-5838.

Parales, R. E., and C. S. Harwood. 1993. Construction and use of a broad-host-range lacZ

transcriptional fusion vector, pHRP309, for Gram-negative bacteria. Gene 133:23-30. Dispensa, M., C. T. Thomas, M.-K. Kim, J. A. Perrotta, J. Gibson, and C. S. Harwood. 1992.

Anaerobic growth of Rhodopseudomonas palustris on 4-hydroxybenzoate is dependent on AadR, a member of the cyclic AMP receptor protein family of transcriptional regulators. J. Bacteriol. 174:5803-5813.

Parales, R. E., and C. S. Harwood. 1992. Characterization of the genes encoding ß- ketoadipate:succinyl-CoA transferase in Pseudomonas putida. J. Bacteriol. 174:4657- 4666.

Han, C.-Y., I. P. Crawford, and C. S. Harwood. 1991. Up-promoter mutations in the trpBA

operon of Pseudomonas aeruginosa. J. Bacteriol. 173:3756-3762. Kim, M.-K., and C. S. Harwood. 1991. Regulation of benzoate-CoA ligase in

Rhodopseudomonas palustris. FEMS Microbiol. Letts. 83:199-204.

Harwood, C. S., R. E. Parales, and M. Dispensa. 1990. Chemotaxis of Pseudomonas putida

toward chlorinated benzoates. Appl. Environ. Microbiol. 56:1501-1503.

Parales, R. E., and C. S. Harwood. 1990. Nucleotide sequence of the gyrB gene of

Pseudomonas putida. Nucleic Acids Res. 18:5880.

Harwood, C. S., K. Fosnaugh, and M. Dispensa. 1989. Flagellation of Pseudomonas putida

and analysis of its motile behavior. J. Bacteriol. 171:4063-4066.

Harwood, C. S. 1989. A methyl-accepting protein is involved in benzoate taxis in

Pseudomonas putida. J. Bacteriol. 171:4603-4608.

Merkel, S. M., A. E. Eberhard, J. Gibson, and C. S. Harwood. 1989. Involvement of coenzyme A thioesters in the anaerobic metabolism of 4-hydroxybenzoate by Rhodopseudomonas palustris. J. Bacteriol. 171:1-7.

Harwood, C. S., and J. Gibson. 1988. Anaerobic and aerobic metabolism of diverse aromatic compounds by the photosynthetic bacterium Rhodopseudomonas palustris. Appl.

Environ. Microbiol. 54:712-717.

Geissler, J. F., C. S. Harwood, and J. Gibson. 1988. Purification and properties of benzoate- coenzyme A ligase, a Rhodopseudomonas palustris enzyme involved in the anaerobic degradation of benzoate. J. Bacteriol. 170:1709-1714.

Harwood, C. S., and L. N. Ornston. 1988. Futile high-level transport activity impairs survival of

Pseudomonas putida under starvation conditions. J. Gen. Microbiol. 134:2421-2427.

Harwood, C. S., and J. Gibson. 1986. Uptake of benzoate by Rhodopseudomonas palustris

grown anaerobically in light. J. Bacteriol. 165:504-509.

Harwood, C. S., and L. N. Ornston. 1984. TOL plasmid can prevent induction of chemotactic responses to aromatic acids. J. Bacteriol. 160:797-800.

Harwood, C. S., M. Rivelli, and L. N. Ornston. 1984. Aromatic acids are chemoattractants for

Pseudomonas putida. J. Bacteriol. 160:622-628.

Harwood, C. S., and E. Canale-Parola. 1983. Spirochaeta isovalercia sp. nov., a marine anaerobe that forms branched-chain fatty acids as fermentation products. Int. J. Syst. Bacteriol. 33:573-579.

Harwood, C. S., H. W. Jannasch, and E. Canale-Parola. 1982. Anaerobic spirochete from a deep- sea hydrothermal vent. Appl. Environ. Microbiol. 44:234-237.

Harwood, C. S., and E. Canale-Parola. 1982. Properties of acetate kinase isozymes and a branched-chain fatty acid kinase from a spirochete. J. Bacteriol. 152:246-254.

Harwood, C. S., and E. Canale-Parola. 1981. Adenosine 5'-triphosphate-yielding pathways of branched-chain amino acid fermentation by a marine spirochete. J. Bacteriol. 148:117- 123.

Harwood, C. S., and E. Canale-Parola. 1981. Branched-chain amino acid fermentation by a marine spirochete: strategy for starvation survival. J. Bacteriol. 148:109-116.

Harwood, C. S., S. S. Bang, P. Baumann, and K. H. Nealson. 1980. Photobacterium logei sp. nov., nom. rev.; Beneckea nereida sp. nov., nom. rev.; and Beneckea gazogenes sp. nov., nom. rev. Int. J. Syst. Bacteriol. 30:655.

Harwood, C. S. 1978. Beneckea gazogenes sp. nov., a red, facultatively anaerobic marine bacterium. Current Microbiol. 1:233-238.

Patents

US patent number 7,745,023; Structured material for the production of hydrogen. Issued 6/29/10.

US patent number 8,268,584: Hydrogen production from microbial strains. Issued 9/18/12 Inventors: Caroline Harwood and Federico Rey

Reviews, proceedings and chapters.

Lang, A. S., C. S. Harwood and J. T. Beatty. 2011. Evolutionary relationships among antenna proteins of purple phototrophic bacteria. IN: R. Burnap and W. Vermaas (eds.), Functional Genomics and Evolution of Photosynthetic Systems, Advances in Photosynthesis and Respiration 33, pp. 253–264, DOI 10.1007/978-94-007-1533-2_10,

McKinlay, J. B. and C. S. Harwood. 2011. Applications of stress response studies: biofuel production. IN: G. Storz and R. Hengge (eds). Bacterial Stress Responses, 2nd ed., Washington, D. C.: ASM Press.

Harwood, C. S. 2010. Role of cyclic di-GMP in Pseudomonas aeruginosa biofilm development.

IN: A. J. Wolfe, and K. L. Visick (eds.) The Second Messenger Cyclic Di-GMP.

(pp.156-172). Washington, DC: ASM Press.

Harwood, C. S. 2009. Degradation of aromatic compounds by purple nonsulfur bacteria

IN: Hunter CN, Daldal, F,Thurnauer MC, and Beatty JT (eds) The Purple Phototrophic Bacteria. Advances in Photosynthesis and Respiration, Vol. 28, pp. 577-594, Springer, Dordrecht, The Netherlands

Harwood, C. S. 2008. Nitrogenase-catalyzed hydrogen production by purple nonsulfur photosynthetic bacteria. p. 259-271. IN: A. Demain, C.S. Harwood and J. Wall (eds.) Bioenergy. American Society for Microbiology Press.

Harwood, C. S. 2008 A microbiologist hopes to disrupt bacterial 'decisions'. Nature. 2008 455: 5.

Parales, R. E., A. Ferrández, and C. S. Harwood.. Chemotaxis in Pseudomonads. 2004. Vol I pp

793-815. In: The Pseudomonads, J.L. Ramos, ed, Kluwer Academic/Plenum Press.

Gibson, J. and C.S. Harwood. 2002. Metabolic diversity in aromatic compound utilization by anaerobic microbes. Annu. Rev. Microbiol. 56:345-369.

Parales, R.E. and C. S. Harwood. 2002. Bacterial chemotaxis to pollutants and plant-derived aromatic molecules. Curr. Opinion in Microbiol.5:266-273.

Aizawa,S-I, C. S. Harwood, and R. J. Kadner. 2000. Signaling components in bacterial locomotion and sensory reception. J. Bacteriol. 182: 1459-1471.

Harwood, C. S., G. Buchhardt, H. Herrmann, and G. Fuchs. 1999. Anaerobic metabolism of aromatic compounds via the benzoyl-CoA pathway. FEMS Microbiol. Rev. 22:439-458

Harwood, C. S. and E. P. Greenberg. 1999. Mega Roles for Microorganisms (review of "Intimate Strangers: Unseen Life on Earth"). Science 286:1096.

Harwood, C. S., and J. Gibson. 1997. Shedding light on anaerobic benzene ring degradation: a process unique to prokaryotes? J. Bacteriol. 179:634-642.

Gibson, J., and C. S. Harwood. 1995. Anaerobic utilization of aromatic carboxylates by bacteria. p. 298-313. IN: R. G. Chaudhry (ed.), Biological degradation and bioremediaton of toxic chemicals. Timber Press, Portland, OR.

Gibson, J., and C. S. Harwood. 1995. Degradation of aromatic compounds by non-sulfur purple bacteria. IN: R. E. Blankenship et al. (eds.), Anoxygenic Photosynthetic Bacteria. p. 991-1003. Kluwer Academic Publishers.

Harwood, C. S., and R. E. Parales. 1996. The b-ketoadipate pathway and the biology of self- identity. Annu. Rev. Microbiol. 50:553-590.

Gibson, J., J. F. Geissler and C. S. Harwood. 1990. Benzoate-coenzyme A ligase from Rhodopseudomonas palustris. Methods in Enzymology (Hydrocarbons and Methylotrophy) 188:154-159.

Harwood, C. S., and E. Canale-Parola. 1984. Ecology of spirochetes. Ann. Rev. Microbiol.

38:161-192